MMSL 2023, 92(2):105-111 | DOI: 10.31482/mmsl.2022.027

EVALUATION OF MALONDIALDEHYDE, HOMOCYSTEINE AND ANTIOXIDANT INFLUENCE CHEMOTHERAPY IN BREAST CANCER PATIENTSOriginal article

Tarteel A. Hamza1, Sinan Adnan Muhsin2, Talat Tariq Khalil ORCID...1*
1 College of Science for Women, University of Babylon, Hilla, Iraq
2 Babylon Health Department, Hilla Teaching Hospital, Hilla, Iraq£

The study was designed to evaluate the medical relevance of total homocysteine (tHcy), total antioxidant capacity (TAC), and malondialdehyde (MDA) before and after chemotherapy for women with breast cancer (BRCA). Blood samples were taken from Oncology Unit in Merjian Teaching hospital in Hilla city (Iraq). Sixty patients suffering from breast cancer (BRCA) were enrolled in this study, and twenty-one apparently healthy subjects were considered as a control group control. We found that significantly increased lipid peroxidation, measured as MDA, was demonstrated in the serum of BRCA patients who were not taken any medication was higher than in the control group (P<0.01) were (25±15) nmol/ml of MDA levels in BRCA patient and (14.5±7.9) nmol/ml of MDA levels in healthy controls. We found that treatment by chemotherapy resulted in a significant increase in MDA levels when compared with MDA levels in patients who were not taken any medication. The tHcy level in BRCA patients before and after treatment were changed. In addition, it is found that the mean serum TAC levels in BRCA patients were significantly less than in the control group. Moreover, a positive correlation was observed between the activity of chemotherapy and MDA levels in the patient and the same correlation between tHcy levels and TAC levels while a negative correlation was observed between TAC levels with MDA levels in the patient group.

Keywords: Malondialdehyde; Total antioxidant capacity; Total homocysteine; Oxidative stress; Breast cancer

Received: May 5, 2022; Revised: June 14, 2022; Accepted: July 13, 2022; Prepublished online: December 1, 2022; Published: June 2, 2023  Show citation

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Hamza, T.A., Muhsin, S.A., & Khalil, T.T. (2023). EVALUATION OF MALONDIALDEHYDE, HOMOCYSTEINE AND ANTIOXIDANT INFLUENCE CHEMOTHERAPY IN BREAST CANCER PATIENTS. MMSL, 92(2), 105-111. doi: 10.31482/mmsl.2022.027
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