MMSL 2024, 93(4):342-354 | DOI: 10.31482/mmsl.2023.043

THE SIGNIFICANCE OF SERUM MIDKINE IN THE DIAGNOSIS AND PROGNOSIS OF INVASIVE DUCTAL CARCINOMA OF THE BREASTOriginal article

Noor Al-Huda J. Muhammad ORCID...1*, Haider A. Jabbar1, Nahidh R. Kazem2
1 Department of Clinical Biochemistry, College of Medicine, University of Al- Qadisiyah, Iraq
2 Department of General Surgery, College of Medicine, Al-Qadisiyah University, Iraq

Background and Objectives: Initial diagnosis of brest cancer (BC) is important for fate and prognosis of the diseases profile, we sought to identify the correlation between Midkine (MK) as a new biomarker with cancer antigen (CA)15-3, liver function test, renal function test, blood cells parameters in individuals with invasive ductal carcinoma.

Methods: The serum MK and CA15-3  of all subjects were measured by the ELISA technique, Liver enzymes were measured by colourimetric methods and neutrophils, and lymphocytes were measured by an Electrical Impedance Cell Counting method (automated machine).

Results: The results of the correlation among serum MK and other parameters in invasive ductal carcinoma of the breast showed a considerable positive correlation among MK and CA15-3 and measured white blood cells. Moreover, there were a weak correlation with Aspartate Aminotransferase (AST) and RBC, while there is no correlation between serum MK and other liver enzymes or blood parameters.

Conclusion: The study results of the correlation between serum MK and other parameters in colorectal carcinoma patients show a significant positive correlation of MK with CA15-3 markers in invasive ductal carcinoma of the breast.

Keywords: Invasive ductal carcinoma; Colorectal carcinoma; Liver enzymes; Lymphocytes; Neutrophils; Midkine

Received: June 6, 2023; Revised: October 4, 2023; Accepted: November 3, 2023; Prepublished online: December 18, 2023; Published: December 2, 2024  Show citation

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Al-Huda Muhammad, N.J., Jabbar, H.A., & Kazem, N.R. (2024). THE SIGNIFICANCE OF SERUM MIDKINE IN THE DIAGNOSIS AND PROGNOSIS OF INVASIVE DUCTAL CARCINOMA OF THE BREAST. MMSL, 93(4), 342-354. doi: 10.31482/mmsl.2023.043
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