MMSL, 2025 (vol. 94), issue 4
DESIGN, CHEMICAL SYNTHESIS, AND IN VITRO EVALUATION OF NOVEL UNCHARGED CHOLINESTERASE REACTIVATOROriginal article
Vendula Hepnarova, Martina Hrabinova, Jakub Opravil, Mojmir Vanek, Eva Mezeiova, Lukas Gorecki, Tomas Kucera, Daniel Jun, Ondrej Soukup, Lubica Muckova, Jan Korabecny
MMSL 2025, 94(4):135-145 | DOI: 10.31482/mmsl.2024.015 
The primary toxicological mechanism of organophosphorus compounds (OPCs) is the irreversible inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine and subsequent cholinergic crisis, which can result in fatal respiratory failure. Conventional oxime reactivators, such as pralidoxime and obidoxime, are limited by their inability to permeate the blood-brain barrier (BBB) and inconsistent efficacy across different OPC types. To address these limitations, we designed a novel non-quaternary oxime reactivator codenamed K1396, with enhanced lipophilicity for improved BBB penetration and dual-binding capability at both the peripheral...
THE IMPACT OF SIMULATION METHOD AND ENVIRONMENT ON STRESS LEVELS AND PERFORMANCE IN MILITARY PARAMEDICS: A PILOT STUDYOriginal article
Jan Páleník, Michal Soták, Karel Roubík, Mikuláš Kosák, Martin Pochop, Adéla Bubeníková, Tomáš Tyll
MMSL 2025, 94(4):146-152 | DOI: 10.31482/mmsl.2024.017
Background: Medical simulation is widely recognized as an essential component of healthcare professional training, including in military training programs around the world. Combat medicine presents unique challenges that can affect the quality of care provided. We aimed to analyze the benefits of medical simulation in the training of combat paramedics.Methods: Two groups of military medics underwent a simulation scenario. One group had previously completed a simulation training with a full-body mannequin, while the second group completed the same training under simulated battle conditions with using imitations of real injuries. The speed and precision...
USABILITY OF MILITARY HEALTH SERVICE TO SUPPORT AN INTEGRATED RESCUE SYSTEMReview article
Vojtěch Humlíček, Josef Fusek
MMSL 2025, 94(4):153-161 | DOI: 10.31482/mmsl.2024.014
The Military Health Service of the Czech Army can support the Integrated Rescue System in the Czech Republic in dealing with emergency and crisis in cases where the basic components cannot ensure the execution of rescue work and clean-up operation by their own forces. The aim of the article is to evaluate the real possibilities of deploying the forces and resources of the Military Health Service to support the integrated rescue system from the point of view of valid legal and internal regulations and to analyze their availability. It was found that the fundamental conditions for the support of the Integrated Rescue System are regulated in the current...
CAROTID ARTERY DISSECTION AND CONNECTIVE TISSUE DISORDERS: A REVIEW OF KNOWN GENE/PROTEIN MUTATION FINDINGSReview article
Petr Malý, Leona Chrastinová, Martin Malý, Jan M. Horáček
MMSL 2025, 94(4):162-169 | DOI: 10.31482/mmsl.2024.016
In this review, we comprehensively analyze the existing literature on the association between connective tissue disorders (CTDs) and carotid artery dissection (CAD), focusing on proven gene and protein mutations. By synthesizing evidence from various studies, we aim to provide a clearer understanding of the underlying mechanisms and potential genetic factors involved in the development of this condition. CAD, a leading cause of stroke in young adults, has been linked to CTDs such as Ehlers-Danlos syndrome, Marfan syndrome, and Loeys-Dietz syndrome, all of which involve genetic mutations that weaken vascular connective tissues. The review reveals that...