MMSL 2024, 93(4):355-363 | DOI: 10.31482/mmsl.2023.037

OLEUROPEIN AND HYDROXYTYROSOL AS ANTIDIABETICS: A REVIEW ON EXTRACTION METHOD, EFFECTIVENESS AND TOXICITY EFFECTReview article

Nurhidayati Harun ORCID...1,4, I Ketut Adnyana ORCID...1, Sophi Damayanti ORCID...2,3, Neng Fisheri Kurniati ORCID...1*
1 Department of Pharmacology-Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesa No.10, Bandung 40132, Indonesia; harunnurhidayati@gmail.com, ketut@itb.ac.id, nfkurniati@itb.ac.id.
2 Department of Pharmacochemistry, School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesa No.10, Bandung 40132, Indonesia; sophi.damayanti@itb.ac.id.
3 University Center of Excellence on Artificial Intelligence for Vision, Natural Language Processing & Big Data Analytics (U-CoE AI-VLB). Jalan Ganesa 10, Bandung 40132, Indonesia; sophi.damayanti@itb.ac.id.
4 STIKes Muhammadiyah Ciamis, Jl. K.H.A. Dahlan No. 20 Ciamis, Indonesia; harunnurhidayati@gmail.com.

Introduction: Olive (Olea uropeae) is a traditional plant containing oleuropein and hydroxytyrosol, which are useful and used empirically for treating diabetes mellitus.

Objective: To review the potential of oleuropein and hydroxytyrosol as an evidence base for diabetes potential treatment and safety.

Methods: This chapter summarizes several studies available on Pubmed and Google Scholar regarding the characteristic method and extraction method as well as the effectiveness and toxicity of oleuropein and hydroxytyrosol in vitro and in vivo.

Result: Oleuropein and hydroxytyrosol are effective antihyperglycemics for treating T2D. They can reduce body weight, basal glycemia, and insulin resistance by stopping the liver from making glucose and stopping the body from absorbing glucose. Several studies have shown that both isolates can control glycemic levels equivalent to free fatty acids and are safe to use.

Conclusion: Oleuropein and hydroxytyrosol are extracted by several methods and can be used as potential anti-diabetics with obesity risk factors. Evidence shows that both isolates are safe for both acute and chronic use.

Keywords: Type 2 diabetes mellitus; obesity; oleuropein; hydroxytyrosol

Received: April 28, 2023; Revised: August 20, 2023; Accepted: September 26, 2023; Prepublished online: November 16, 2023; Published: December 2, 2024  Show citation

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Harun, N., Ketut Adnyana, I., Damayanti, S., & Kurniati, N.F. (2024). OLEUROPEIN AND HYDROXYTYROSOL AS ANTIDIABETICS: A REVIEW ON EXTRACTION METHOD, EFFECTIVENESS AND TOXICITY EFFECT. MMSL, 93(4), 355-363. doi: 10.31482/mmsl.2023.037
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