Background and Objectives: Liver cirrhosis is a serious and chronic condition that affects the liver, causing irreversible damage and scarring. The present study is designed to find out a possible correlation of hepatitis B virus (HBV) with cirrhosis by microRNA.

Methods: The fold expression of the identified microRNAs by RT qPCR was determined to estimate the concentrations of circulating microRNAs in all samples. This study's main objective was to examine microRNA21-5p expression in liver cirrhosis patients. To extract RNA from samples of whole blood from all specimens in EDTA tubes, the study entailed collecting 60 specimens from the perspective of patients and samples pooled from 60 healthy participants (control group). Data on the patient are gathered for the study.

Result: Researchers compared the levels of miRNA-146a in individuals with hepatic cirrhosis and control subjects, and the findings were clear. individuals with hepatic cirrhoses and controls, correspondingly, had mean levels of miRNA-146a of 2.38 3.25 and 1.12 1.01; this alteration was statistically noteworthy (P = 0.002). Both the miRNA-146a cut-off value and the prediction of liver cirrhosis disease should be considered diagnostic or adjuvant diagnostic tests. With sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the curve (AUC) of 58.3%, 53.3%, 55.6%, 56.1%, and 0.610 (0.508 -0.711), the miRNA-146a cut-off value was > 0.91-fold. The current findings suggest that miRNA-146a is a subpar diagnostic marker.

Conclusion: Compared to controls, patients with cirrhosis had significantly higher levels of micro-RNA146A. When compared to those who are healthy, this finding demonstrates that micro-RNA 146A may influence the prognosis of cirrhosis.

Keywords: Liver Cirrhosis; microRNA-146a; HBV