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MODULATION OF AUTISM SYMPTOMS IN A 13-YEAR-OLD BOY BY FOOD SUPPLEMENT JUVENILCase reportJela Hrnciarova, Anna Hanusova, Tereza Horakova, Josef Fusek, Klara Kubelkova, Ales Macela[Ahead of Print]MMSL X:X | DOI: 10.31482/mmsl.2025.006 Antidepressants, antipsychotics, anti-anxiety drugs, or sleeping pills are most often used to treat autism spectrum disorders. The treatment thus focuses on the manifestations accompanying autism, such as inattention, irritability, or sleep disorders, but does not address the essence of the social deficits of autistic children. In addition, drug treatment is often poorly tolerated. Since a certain association of autism with gut microbiota dysbiosis has been demonstrated, and given the existence of the microbiota-gut-brain axis, it can be assumed that modulation of the gut microbiota could contribute to the treatment of the essence of some Autism Spectrum Disorders category manifestations. Here, we present an example of the use of the nutritional supplement Juvenil to alleviate the manifestations of Autism Spectrum Disorders in a patient with Asperger’s syndrome. |
JUVENIL, A NATURAL IMMUNE BOOSTER AFFECTING BIOLOGICAL RESPONSES THROUGH MODULATION OF GUT MICROBIOTA COMPOSITIONReview articleVanda Bostik, Klára Kubelková, Aleš MacelaMMSL 2024, 93(4):364-376 | DOI: 10.31482/mmsl.2023.039 Juvenil, a nontoxic extract of bovine blood, is registered as a dietary supplement having no side effects. It contains a broad spectrum of free amino acids, as well as small proteins and oligopeptides (molecular weights up to 10 kDa), various nucleotides, and small amounts of phospholipids. The complex of these exclusively natural components has been shown to support physiological responses of supplemented organisms.Juvenil has been studied for several decades using a wide range of both experimental and clinical studies. Analyses have shown that it acts directly neither on individual functional systems of the body nor on individual metabolic processes. Current findings indicate that modulatory effects of Juvenil occur through modulation of gut microbiota composition, which is associated with the modulation of microbiota–gut–brain axis signaling. In murine model that modulatory effect is reflected in the expression of an early activation c-Fos marker in specific parts of the brain.In this review we present a set of findings about Juvenil, which has a wide range of positive effects on the functional systems of organisms. These effects can be used to strenghten the resistance, immunity, and regeneration of human beings. According to its effects Juvenil can be classified as a psychobiotics. |
MOLECULAR CHARACTERIZATION OF ALCOHOL–ETHER EXTRACT FROM BOVINE TISSUEOriginal articleKlara Kubelkova, Martin Hubalek, Pavel Rehulka, Helena Rehulkova, David Friedecky, Jitka Zakova, Ales MacelaMMSL 2021, 90(3):120-136 | DOI: 10.31482/mmsl.2021.012 It is usual for information to be unavailable regarding the molecular composition of extracts from herbs or animal tissues that are popular in folk medicine. Here, we present analysis of the alcohol–ether extract from bovine tissue analogous to the basic substance used in such commercial products as Retisin, Imuregen, Actovegin, and Solcoseryl. The tested extract contains a whole spectrum of free amino acids, small proteins and oligopeptides of molecular weight up to 10 kDa, various nucleotides, and a small amount of phospholipids. Among the molecules that can explain some biological activities of the extract were identified those of taurine (2-aminoethanesulfonic acid, a derivative of the amino acid cysteine), several defensins, and bactericidal hemoglobin fragments known as hemocidins. All those molecules identified are natural components of bovine tissues, and a substantial number of them might be biologically active in vivo. Others are sources of readily available nutrients. |
WORKSHOP 2022: POSSIBLE MODULATOR APPLICATIONS FOR BIOLOGICAL REACTIONSLetter to the editorVanda Boštíková, Aleš MacelaMMSL 2022, 91(2):164-166 During the last weekend of February, from Friday 25 February to Saturday 26 February 2022, a workshop was held at the Rajská zahrada hotel in Nové Město nad Metují, marked by lectures and discussions on the application of modulators of biological reactions. |
A SHORT HISTORY OF IMUREGEN – AN ORIGINAL TISSUE EXTRACTReview articleKlara Kubelkova, Ales MacelaMMSL 2019, 88(3):115-120 | DOI: 10.31482/mmsl.2019.008 Imuregen is a unique dietary supplement that was developed by leading Czech immunologists, made and distributed from the Czech Republic, and first came out in the 1950s. Imuregen boasts of decades of research and clinical exposure. It was created for the immune system sourced only from all natural ingredients that support cellular immunity and energy, tissue regeneration, wound healing, endocrine gland repair, intestinal integrity, memory enhancement, and has antitumor effects. |
POSUDKOVA PROBLEMATIKA PRI VYBERU A ZARAZOVANI VOJENSKYCH RIDICUVladimír Jelínek, Petr KrekuleVZL 1981, 50(4):166-172 |


